3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	TGF-beta receptor type-1 Protein (Entity type)	Kd
3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Vascular endothelial growth factor receptor 1 Protein (Entity type)	Ki
3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	STE20-like serine/threonine-protein kinase Protein (Entity type)	Ki
3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Vascular endothelial growth factor receptor 2 Protein (Entity type)	IC50
3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Fibroblast growth factor receptor 2 Protein (Entity type)	IC50
3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Vascular endothelial growth factor A, long form Protein (Entity type)	IC50
3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Activin receptor type-1B Protein (Entity type)	Kd
3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Angiopoietin-1 receptor Protein (Entity type)	IC50
3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Proto-oncogene tyrosine-protein kinase receptor Ret Protein (Entity type)	IC50
3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Fibroblast growth factor receptor 1 Protein (Entity type)	IC50

3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
TGF-beta receptor type-1
Protein (Entity type)
Kd

3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Vascular endothelial growth factor receptor 1
Protein (Entity type)
Ki

3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
STE20-like serine/threonine-protein kinase
Protein (Entity type)
Ki

3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Vascular endothelial growth factor receptor 2
Protein (Entity type)
IC50

3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Fibroblast growth factor receptor 2
Protein (Entity type)
IC50

3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Vascular endothelial growth factor A, long form
Protein (Entity type)
IC50

3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Activin receptor type-1B
Protein (Entity type)
Kd

3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Angiopoietin-1 receptor
Protein (Entity type)
IC50

3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Proto-oncogene tyrosine-protein kinase receptor Ret
Protein (Entity type)
IC50

3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Fibroblast growth factor receptor 1
Protein (Entity type)
IC50

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Knowledge Graph Assertions

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