N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	RARRES2 Gene (Entity type)	-0.0037091696
N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DCN Gene (Entity type)	-0.0039361464
N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	AKR1C2 Gene (Entity type)	-0.0035045606
N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	AKR1C3 Gene (Entity type)	-0.003949802
N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MAGEA12 Gene (Entity type)	0.0043972675
N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DKK1 Gene (Entity type)	0.0035211446
N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DLK1 Gene (Entity type)	0.0040321206
N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	EMP1 Gene (Entity type)	-0.0032243212
N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Aurora kinase B Protein (Entity type)	IC50
N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CFI Gene (Entity type)	-0.0035567896

N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
RARRES2
Gene (Entity type)
-0.0037091696

N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DCN
Gene (Entity type)
-0.0039361464

N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
AKR1C2
Gene (Entity type)
-0.0035045606

N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
AKR1C3
Gene (Entity type)
-0.003949802

N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MAGEA12
Gene (Entity type)
0.0043972675

N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DKK1
Gene (Entity type)
0.0035211446

N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DLK1
Gene (Entity type)
0.0040321206

N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
EMP1
Gene (Entity type)
-0.0032243212

N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Aurora kinase B
Protein (Entity type)
IC50

N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CFI
Gene (Entity type)
-0.0035567896

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