1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MEIS1 Gene (Entity type)	0.0042057466
1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	S100A8 Gene (Entity type)	0.0037545487
1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Estrogen receptor Protein (Entity type)	IC50
1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CTSS Gene (Entity type)	0.004051847
1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLAAT3 Gene (Entity type)	-0.00392417
1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	BTG3 Gene (Entity type)	-0.0030964836
1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	S100A9 Gene (Entity type)	0.004699863
1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MSMO1 Gene (Entity type)	0.0040521896
1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	(4-Bromo-2-fluoro-phenyl)-[6-methoxy-7-(piperidin-4-ylmethoxy)-quinazolin-4-yl]-amine Compound (Entity type)	0.390939325094223
1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Osteoporosis, Postmenopausal Disease or Phenotype (Entity type)

1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MEIS1
Gene (Entity type)
0.0042057466

1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
S100A8
Gene (Entity type)
0.0037545487

1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Estrogen receptor
Protein (Entity type)
IC50

1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CTSS
Gene (Entity type)
0.004051847

1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLAAT3
Gene (Entity type)
-0.00392417

1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
BTG3
Gene (Entity type)
-0.0030964836

1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
S100A9
Gene (Entity type)
0.004699863

1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MSMO1
Gene (Entity type)
0.0040521896

1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
(4-Bromo-2-fluoro-phenyl)-[6-methoxy-7-(piperidin-4-ylmethoxy)-quinazolin-4-yl]-amine
Compound (Entity type)
0.390939325094223

1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
Osteoporosis, Postmenopausal
Disease or Phenotype (Entity type)

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Knowledge Graph Assertions

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