(E)-(3R,5S)-7-[4-(4-Fluoro-phenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid anion (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View (E)-(3R,5S)-7-[4-(4-Fluoro-phenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid anion's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
(E)-(3R,5S)-7-[4-(4-Fluoro-phenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid anion Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ACAT2 Gene (Entity type)	0.004632535
(E)-(3R,5S)-7-[4-(4-Fluoro-phenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid anion Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	POU2AF1 Gene (Entity type)	-0.006210689
(E)-(3R,5S)-7-[4-(4-Fluoro-phenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid anion Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	IGFBP1 Gene (Entity type)	-0.004290319
(E)-(3R,5S)-7-[4-(4-Fluoro-phenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid anion Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CXCL1 Gene (Entity type)	-0.005170476
(E)-(3R,5S)-7-[4-(4-Fluoro-phenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid anion Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HSPA8 Gene (Entity type)	-0.0047444776
(E)-(3R,5S)-7-[4-(4-Fluoro-phenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid anion Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Familial hypercholesterolemia - heterozygous Disease or Phenotype (Entity type)
(E)-(3R,5S)-7-[4-(4-Fluoro-phenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid anion Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LAP3 Gene (Entity type)	-0.003957072
(E)-(3R,5S)-7-[4-(4-Fluoro-phenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid anion Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LYZ Gene (Entity type)	0.003850287
(E)-(3R,5S)-7-[4-(4-Fluoro-phenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid anion Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	IKZF1 Gene (Entity type)	-0.005599254
(E)-(3R,5S)-7-[4-(4-Fluoro-phenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid anion Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	GUSBP3 Gene (Entity type)	0.00403714