N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TSPAN8 Gene (Entity type)	0.003929738
N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TUBB2A Gene (Entity type)	-0.004047899
firategrast Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide Compound (Entity type)	0.3088337182998657
N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MMD Gene (Entity type)	0.003655546
N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	REG1A Gene (Entity type)	0.0036109376
N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	FTI 276 Compound (Entity type)	0.4117010831832886
N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TAGLN Gene (Entity type)	-0.004143927
N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Rho-associated protein kinase 1 Protein (Entity type)	IC50
N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PODXL Gene (Entity type)	-0.0036989427
N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	UCP2 Gene (Entity type)	0.0039612423

N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TSPAN8
Gene (Entity type)
0.003929738

N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TUBB2A
Gene (Entity type)
-0.004047899

firategrast
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide
Compound (Entity type)
0.3088337182998657

N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MMD
Gene (Entity type)
0.003655546

N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
REG1A
Gene (Entity type)
0.0036109376

N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
FTI 276
Compound (Entity type)
0.4117010831832886

N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TAGLN
Gene (Entity type)
-0.004143927

N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Rho-associated protein kinase 1
Protein (Entity type)
IC50

N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PODXL
Gene (Entity type)
-0.0036989427

N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
UCP2
Gene (Entity type)
0.0039612423

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