isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CFH Gene (Entity type)	-0.004603801
isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CPB1 Gene (Entity type)	0.004465257
isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CD40 Gene (Entity type)	-0.0047931587
isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Swainsonine Compound (Entity type)	0.272407591342926
isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	S-ruxolitinib Compound (Entity type)	0.3548267483711242
isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Bile acid receptor Protein (Entity type)	EC50
isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SERPINB3 Gene (Entity type)	-0.0046179765
isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SLC38A1 Gene (Entity type)	-0.0056069833
isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TNS3 Gene (Entity type)	-0.0048089204
isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Isoniazid Compound (Entity type)	0.3003415465354919

isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CFH
Gene (Entity type)
-0.004603801

isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CPB1
Gene (Entity type)
0.004465257

isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CD40
Gene (Entity type)
-0.0047931587

isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Swainsonine
Compound (Entity type)
0.272407591342926

isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
S-ruxolitinib
Compound (Entity type)
0.3548267483711242

isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Bile acid receptor
Protein (Entity type)
EC50

isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SERPINB3
Gene (Entity type)
-0.0046179765

isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SLC38A1
Gene (Entity type)
-0.0056069833

isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TNS3
Gene (Entity type)
-0.0048089204

isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Isoniazid
Compound (Entity type)
0.3003415465354919

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