(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View (S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CDH1 Gene (Entity type)	-0.006482477
(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	AK4 Gene (Entity type)	-0.0051357727
(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	RELB Gene (Entity type)	0.009537054
(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	PF-477736 Compound (Entity type)	0.4625485837459564
(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein kinase Chk1 Protein (Entity type)	IC50
(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HMGCS1 Gene (Entity type)	0.008420665
PF-477736 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea Compound (Entity type)	0.4625485837459564
(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MELK Gene (Entity type)	-0.0052044303
(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DAXX Gene (Entity type)	-0.0050346213
(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ATAD2 Gene (Entity type)	-0.0050142966

(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CDH1
Gene (Entity type)
-0.006482477

(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
AK4
Gene (Entity type)
-0.0051357727

(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
RELB
Gene (Entity type)
0.009537054

(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
PF-477736
Compound (Entity type)
0.4625485837459564

(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein kinase Chk1
Protein (Entity type)
IC50

(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HMGCS1
Gene (Entity type)
0.008420665

PF-477736
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea
Compound (Entity type)
0.4625485837459564

(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MELK
Gene (Entity type)
-0.0052044303

(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DAXX
Gene (Entity type)
-0.0050346213

(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ATAD2
Gene (Entity type)
-0.0050142966

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Knowledge Graph Assertions

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