Cell Surface Targets for Individual Cancer Patients Analyzed with Common Fund Datasets
Given RNA-seq samples from a patient tumor, we screen for targets which are highly expressed in the tumor but lowly expressed across all healthy human tissues in GTEx. Detailed information about the selected target are queried from several DCCs.
FEATURED
Mild Cognitive Impairment Use Case
Find all IDG and GTEx assertions that may be related to mild cognitive impairment and any tissue type.
FEATURED
Exploring the Similar Biological Pathways Implicated in Aging and Exercise
The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to assess molecular changes that occur in response to physical activity [1]. To investigate the common biological underpinnings of aging and exercise and discover genes that are induced and repressed due to exercise and also change in levels due to aging, we crossed the aging signatures created from GTEx [2] with the MoTrPAC rat endurance training [3] gene sets.
FEATURED
Cell Surface Targets for Individual Cancer Patients Analyzed with Common Fund Datasets
Given RNA-seq samples from a patient tumor, we screen for targets which are highly expressed in the tumor but lowly expressed across all healthy human tissues in GTEx. Detailed information about the selected target are queried from several DCCs.
FEATURED
Mild Cognitive Impairment Use Case
Find all IDG and GTEx assertions that may be related to mild cognitive impairment and any tissue type.
FEATURED
Exploring the Similar Biological Pathways Implicated in Aging and Exercise
The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to assess molecular changes that occur in response to physical activity [1]. To investigate the common biological underpinnings of aging and exercise and discover genes that are induced and repressed due to exercise and also change in levels due to aging, we crossed the aging signatures created from GTEx [2] with the MoTrPAC rat endurance training [3] gene sets.
FEATURED
Cell Surface Targets for Individual Cancer Patients Analyzed with Common Fund Datasets
Given RNA-seq samples from a patient tumor, we screen for targets which are highly expressed in the tumor but lowly expressed across all healthy human tissues in GTEx. Detailed information about the selected target are queried from several DCCs.
FEATURED
Mild Cognitive Impairment Use Case
Find all IDG and GTEx assertions that may be related to mild cognitive impairment and any tissue type.
FEATURED
Exploring the Similar Biological Pathways Implicated in Aging and Exercise
The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to assess molecular changes that occur in response to physical activity [1]. To investigate the common biological underpinnings of aging and exercise and discover genes that are induced and repressed due to exercise and also change in levels due to aging, we crossed the aging signatures created from GTEx [2] with the MoTrPAC rat endurance training [3] gene sets.
ALL USE CASES
Explore different use cases that utilizes data from different CFDE participating programs
Data Distillery Knowledge Graph
Frontotemporal Dementia Use Case
For genes that are correlated with frontotemporal dementia, identify extracellular RNAs (exRNAs) that may be detected in human biofluids and thus serve as non-invasive disease biomarkers.
Get-Gene-Set-Go
Exploring the Similar Biological Pathways Implicated in Aging and Exercise
Aging signatures are gene expression changes linked to aging. To investigate common biological aspects of aging and exercise and identify genes affected by both, the study matched aging signatures from GTEx with MoTrPAC rat endurance training gene sets.
Playbook Workflow Builder
Related Proteins/Metabolites across DCCs
Using directly related proteins to a gene of interest, we return a slew of related information to the gene protein network from different DCCs.
Data Distillery Knowledge Graph
CES1 Use Case
Display drugs that up or down regulate the gene CES1 from LINCS as well as tissues where it is highly expressed based on assertions from GTEx.
Data Distillery Knowledge Graph
Liquid Biopsy of Dexamethasone Response
Find genes that are up-regulated by dexamethasone, (2) loci expressed in exRNA that overlap RBP binding regions, (3) the RBP that overlaps the locus, and (4) the biofluid(s) where locus was expressed in exRNA.
Data Distillery Knowledge Graph
Mild Cognitive Impairment Use Case
Find all IDG and GTEx assertions that may be related to mild cognitive impairment and any tissue type.
Playbook Workflow Builder
CFDE Knowledge about a Variant
We query several CFDE data sources for information about the variant provided and about the closest gene to that variant.
Playbook Workflow Builder
Associations between Two Variants
Given two variants, we find their closest genes and present combined knowledge about them including their expression in tumors & healthy tissue, interactions between the two proteins, and gene sets containing the two genes.
Playbook Workflow Builder
Cell Surface Targets for Individual Cancer Patients Analyzed with Common Fund Datasets
Given RNA-seq samples from a patient tumor, we screen for targets which are highly expressed in the tumor but lowly expressed across all healthy human tissues in GTEx. Detailed information about the the selected target are queried from several DCCs.
Data Distillery Knowledge Graph
EnzymeMiner
Select a drug processing enzyme to view drugs that up or down regulate it from LINCS as well as tissues where it is highly expressed based on data from GTEx.