FEATURED

Cell Surface Targets for Individual Cancer Patients Analyzed with Common Fund Datasets

Given RNA-seq samples from a patient tumor, we screen for targets which are highly expressed in the tumor but lowly expressed across all healthy human tissues in GTEx. Detailed information about the selected target are queried from several DCCs.
Cell Surface Targets for Individual Cancer Patients Analyzed with Common Fund Datasets
FEATURED

Mild Cognitive Impairment Use Case

Find all IDG and GTEx assertions that may be related to mild cognitive impairment and any tissue type.
Mild Cognitive Impairment Use Case
FEATURED

Exploring the Similar Biological Pathways Implicated in Aging and Exercise

The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to assess molecular changes that occur in response to physical activity [1]. To investigate the common biological underpinnings of aging and exercise and discover genes that are induced and repressed due to exercise and also change in levels due to aging, we crossed the aging signatures created from GTEx [2] with the MoTrPAC rat endurance training [3] gene sets.
Exploring the Similar Biological Pathways Implicated in Aging and Exercise

ALL USE CASES

Explore different use cases that utilizes data from different CFDE participating programs

Frontotemporal Dementia Use Case
Data Distillery Knowledge Graph

Frontotemporal Dementia Use Case

For genes that are correlated with frontotemporal dementia, identify extracellular RNAs (exRNAs) that may be detected in human biofluids and thus serve as non-invasive disease biomarkers.
Frontotemporal Dementia Use Case
Exploring the Similar Biological Pathways Implicated in Aging and Exercise
Get-Gene-Set-Go

Exploring the Similar Biological Pathways Implicated in Aging and Exercise

Aging signatures are gene expression changes linked to aging. To investigate common biological aspects of aging and exercise and identify genes affected by both, the study matched aging signatures from GTEx with MoTrPAC rat endurance training gene sets.
Exploring the Similar Biological Pathways Implicated in Aging and Exercise
Related Proteins/Metabolites across DCCs
Playbook Workflow Builder

Related Proteins/Metabolites across DCCs

Using directly related proteins to a gene of interest, we return a slew of related information to the gene protein network from different DCCs.
Related Proteins/Metabolites across DCCs
CES1 Use Case
Data Distillery Knowledge Graph

CES1 Use Case

Display drugs that up or down regulate the gene CES1 from LINCS as well as tissues where it is highly expressed based on assertions from GTEx.
CES1 Use Case
Liquid Biopsy of Dexamethasone Response
Data Distillery Knowledge Graph

Liquid Biopsy of Dexamethasone Response

Find genes that are up-regulated by dexamethasone, (2) loci expressed in exRNA that overlap RBP binding regions, (3) the RBP that overlaps the locus, and (4) the biofluid(s) where locus was expressed in exRNA.
Liquid Biopsy of Dexamethasone Response
Mild Cognitive Impairment Use Case
Data Distillery Knowledge Graph

Mild Cognitive Impairment Use Case

Find all IDG and GTEx assertions that may be related to mild cognitive impairment and any tissue type.
Mild Cognitive Impairment Use Case
CFDE Knowledge about a Variant
Playbook Workflow Builder

CFDE Knowledge about a Variant

We query several CFDE data sources for information about the variant provided and about the closest gene to that variant.
CFDE Knowledge about a Variant
Associations between Two Variants
Playbook Workflow Builder

Associations between Two Variants

Given two variants, we find their closest genes and present combined knowledge about them including their expression in tumors & healthy tissue, interactions between the two proteins, and gene sets containing the two genes.
Associations between Two Variants
Cell Surface Targets for Individual Cancer Patients Analyzed with Common Fund Datasets
Playbook Workflow Builder

Cell Surface Targets for Individual Cancer Patients Analyzed with Common Fund Datasets

Given RNA-seq samples from a patient tumor, we screen for targets which are highly expressed in the tumor but lowly expressed across all healthy human tissues in GTEx. Detailed information about the the selected target are queried from several DCCs.
Cell Surface Targets for Individual Cancer Patients Analyzed with Common Fund Datasets
EnzymeMiner
Data Distillery Knowledge Graph

EnzymeMiner

Select a drug processing enzyme to view drugs that up or down regulate it from LINCS as well as tissues where it is highly expressed based on data from GTEx.
EnzymeMiner