PR001120 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20250922.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8XM6R

Description:Environmental factors, mucosal permeability and defective immunoregulation drive overactive immunity to a subset of resident intestinal bacteria that mediate multiple inflammatory conditions. GUT-103 and GUT-108, live biotherapeutic products rationally designed to complement missing or underrepresented functions in the dysbiotic microbiome of IBD patients, address upstream targets, rather than targeting a single cytokine to block downstream inflammation responses. GUT-103, composed of 17 strains that synergistically provide protective and sustained engraftment in the IBD inflammatory environment, prevented, and treated chronic immune-mediated colitis. Therapeutic application of GUT-108 reversed established colitis in a humanized chronic T cell-mediated mouse model. It decreased pathobionts while expanding resident protective bacteria; produced metabolites promoting mucosal healing and immunoregulatory responses; decreased inflammatory cytokines and Th-1 and Th-17 cells; and induced interleukin-10-producing colonic regulatory cells, and IL-10-independent homeostatic pathways. We propose GUT-108 for treating and preventing relapse for IBD and other inflammatory conditions characterized by unbalanced microbiota and mucosal permeability.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU001825 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001120 project
	SA163569 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001120 project
	SA163576 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001120 project
	SA163782 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001120 project
	SA163535 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001120 project
	SA163514 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001120 project
	SA163625 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001120 project
	SA163778 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001120 project
	SA163605 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001120 project