Description:Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease with unclear etiology and limited efficacious treatments. Dysregulated cellular metabolism has been shown to participate in several pathologic processes, however, its role in the pathogenesis of pulmonary fibrosis remains largely unknown. In this study, we used mouse model of bleomycin-induced lung fibrosis and global metabolomics to examine the metabolites differences in control mouse lungs and fibrotic mouse lungs. This metabolomic profiling provides further insights into the pathogenesis of pulmonary injury and fibrosis.