PR001975 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20250922.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8F723

Description:Pathological changes in Alzheimer’s disease (AD) begin decades before cognitive symptoms appear. Chronic exposure to environmental neurotoxins like manganese (Mn) from sources such as air pollution and water can impact disease development across decades. Mn toxicity can lead to motor and neuropsychiatric symptoms resembling Parkinson's disease, attributed to its accumulation in globus pallidus. In contrast, the impact of chronic lower-level exposures on normal and neuropathological brain function is unknown. We tested whether 10 months of a high Mn diet (2400 ppm) could alter aspects of glutamate signaling in APP/PSEN1 mice to further exacerbate cognitive impairments compared to control fed animals (70 ppm). This study supports the potential role for chronic environmental exposures in the development of Alzheimer’s disease associated neuropathology.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU003295 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001975 project
	SA343260 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001975 project
	SA343315 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001975 project
	SA343298 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001975 project
	SA343280 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001975 project
	SA343220 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001975 project
	SA343238 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001975 project
	SA343265 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001975 project
	SA343277 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001975 project

PPR00001

Project (Entity type)

Metabolomics

SU003295

Subject (Entity type)

A subject from Metabolomics produced as part of the PR001975 project

SA343260

Biosample (Entity type)