PR002151 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20250922.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8KG00

Description:Using 13C-inulin as a tracer, we tracked the biosynthesis of polyamines in the human and mouse fecal microbiome. Additionally, single-strain SIRM analyses was used to explore functional gut microbes. Liquid chromatography-high resolution mass spectrometry analysis revealed distinct 13C enrichment profiles for polyamines. SIRM analyses were performed using a Q-Exactive HF mass spectrometer, equipped with an Ion Max API source and a HESI II probe, and were coupled to a Dionex UltiMate 3000 UHPLC system (Thermo Fisher Scientific). The findings revealed a novel de novo SPD biosynthesis pathway in the human gut microbiome, and Bacteroides (including B.fragilis and B.thetaiotaomicron) contributed to the biosynthesis of polyamines, underscoring the importance of polyamine bioanalysis in aligning gut microbial functions to host intestinal health.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU003634 Subject (Entity type)	A subject from Metabolomics produced as part of the PR002151 project
	SA385808 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002151 project
	SA385811 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002151 project
	SA385797 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002151 project
	SA385820 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002151 project
	SA385815 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002151 project
	SA385812 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002151 project
	SA385804 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002151 project
	SA385800 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002151 project

PPR00001

Project (Entity type)

Metabolomics

SU003634

Subject (Entity type)

A subject from Metabolomics produced as part of the PR002151 project

SA385808

Biosample (Entity type)