PR002367 (Project)

Description:Abnormal lipoprotein profiles have been frequently described in association with atherogenic cardiovascular diseases. The relevance of lipoproteins in human cardiovascular health with ageing, which commonly manifests as heart failure in older adults, is less often investigated. Capitalizing on 1H NMR spectroscopy which identifies lipoprotein subclasses with great detail, we explored in-depth associations between 112 lipoproteins and cardiac function of N=474 unique older adults, hypothesizing that specific lipoproteins may be associated with cardiac ageing.Decreases in intermediate density LDLs (1.034-1.037 g/mL) and increases in intermediate density VLDLs (0.961-0.995 g/mL) were observed among older adults with poorer cardiac function. There was heterogeneous distribution of low density (0.950-0.961 g/mL) VLDL fractions, which became more prominent in patients with poor cardiac function. Prominent apolipoprotein-A increases specific to those with poorer cardiac function were observed among those taking lipid lowering medications, localized to specific lower density HDL fractions (1.063-1.112 g/mL).