PR001359 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20250922.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8270X

Description:Despite recent advances, diabetic nephropathy (DN) remains a major public health concern. The precise underlying molecular mechanisms of DN remain elusive. Accumulating recent evidence suggests that mitochondrial integrity and lipid metabolism in podocytes significantly contribute to the pathogenesis of DN. However, the interplay between these two key metabolic regulators of DN is not fully understood. This study examines the role of ChREBP (carbohydrate-response element-binding protein), a master regulator of lipogenesis, on mitochondrial morphology and progression of DN. Our findings suggest that diabetic mice with podocyte-specific deletion of ChREBP are protected against mitochondrial fragmentation and progression of DN. Using liquid chromatography coupled with mass spectrometry, we identified the central role of ChREBP-induced plasmalogen phospholipids in linking mitochondrial lipidomes with mitochondrial dynamics in DN.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU002230 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001359 project
	SA205785 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001359 project
	SA205778 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001359 project
	SA205779 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001359 project
	SA205780 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001359 project
	SA205786 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001359 project
	SA205787 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001359 project
	SA205782 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001359 project
	SA205783 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001359 project

PPR00001

Project (Entity type)

Metabolomics

SU002230

Subject (Entity type)

A subject from Metabolomics produced as part of the PR001359 project

SA205785

Biosample (Entity type)