PR002718 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20251214.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8B26Z

Description:Bone marrow mesenchymal stromal cells (BMSCs) are a type of multipotent stem cell found in the bone marrow stroma that can differentiate into various cell types, support the bone marrow's microenvironment, and regulate other stem cells. Their key functions include providing physical support to hematopoietic stem cells, secreting factors that control their homeostasis, and undergoing differentiation into bone, cartilage, and fat cells. BMSCs are also being explored for various cell therapies due to their ability to be expanded in vitro. To determine the role of taurine in regulating metabolism of bone marrow mesenchymal stromal cells (MSCs), we carried out untargeted metabolomic analysis of murine taurine transporter (TauT) wild-type and knockout MSCs. Briefly, 16 week old TauT+/+ and TauT-/- mice were sacrificed, stromal populations were isolated and magnetically enriched or flow sorted for MSCs. Next, untargeted metabolomic analysis was carried out to identify metabolic changes induced by inhibiting taurine uptake in MSCs. This analysis identified inositol metabolism as a downstream effector of taurine in MSCs.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU004455 Subject (Entity type)	A subject from Metabolomics produced as part of the PR002718 project
	ST004302 Rawfiles.zip File (Entity type)	A 895 MB file from Metabolomics produced from OBI:0003097 as part of the PR002718 project
	ST004302 AN007158 Results.txt File (Entity type)	A 91.8 KB file from Metabolomics produced from OBI:0003097 as part of the PR002718 project
	ST004302 AN007159 Results.txt File (Entity type)	A 92.6 KB file from Metabolomics produced from OBI:0003097 as part of the PR002718 project
	SA505189 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002718 project
	SA505187 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002718 project
	SA505194 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002718 project
	SA505190 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002718 project
	SA505186 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002718 project