Description:The aim of this study was to identify circulating markers that correlated with severity and mortality in sepsis. We performed metabolomic profiling on 4 cohorts: 1) patients with septic shock, 2) patients with bacteremia without sepsis, 3) cardiogenic shock, and 4) healthy ambulatory controls. We found a set of metabolites that out outperformed lactate in their ability to distinguish survivors and non-survivors of sepsis.