PR000828 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20250922.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8NQ4J

Description:To investigate the metabolic alterations in response to immune checkpoint blockade, we comprehensively profiled serum metabolites in advanced melanoma and renal cell carcinoma patients treated with nivolumab, an antibody against programmed cell death protein 1 (PD1). We identified serum kynurenine/tryptophan ratio increases as an adaptive resistance mechanism associated with worse overall survival. This advocates for patient stratification and metabolic monitoring in immunotherapy clinical trials including those combining PD1 blockade with IDO/TDO inhibitors.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU001305 Subject (Entity type)	A subject from Metabolomics produced as part of the PR000828 project
	SU001304 Subject (Entity type)	A subject from Metabolomics produced as part of the PR000828 project
	SU001303 Subject (Entity type)	A subject from Metabolomics produced as part of the PR000828 project
	SA089415 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000828 project
	SA089516 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000828 project
	SA088546 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000828 project
	SA089793 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000828 project
	SA089103 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000828 project
	SA088471 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000828 project

PPR00001

Project (Entity type)

Metabolomics

SU001305

Subject (Entity type)

A subject from Metabolomics produced as part of the PR000828 project

SU001304

Subject (Entity type)

A subject from Metabolomics produced as part of the PR000828 project

SU001303

Subject (Entity type)

A subject from Metabolomics produced as part of the PR000828 project

SA089415

Biosample (Entity type)