PR000458 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20250922.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8VG74

Description:This proposal addresses a gap in knowledge about biomarkers for insulin resistance and diabetes. It remains unclear why some populations develop diabetes at higher rates than others and whether prevention and treatment strategies should also differ. The main goal of the current study is to determine the impact of body composition and physical activity on biomarkers for insulin resistance in American Indian adolescents. We propose to use a targeted metabolomic approach to measure amino compounds and fatty acids in plasma. We will address these goals by exploring two Specific Aims: 1. To determine the effects of obesity and physical activity on circulating biomarkers for diabetes and metabolic disease risk in American Indian youth. Plasma samples used for measurements of amino compounds and fatty acids will be acquired from boys and girls 11-21 years old classified as, a) obese, low habitual physical activity and low fitness; b) normal weight, low habitual physical activity and low fitness; or, c) normal weight, high habitual physical activity and high fitness. 2. To determine the impact of exercise training on circulating biomarkers for diabetes and metabolic disease risk in obese American Indian youth. The same obese group tested in the cross-sectional comparison in Aim 1 will complete 16 weeks of aerobic exercise training. Plasma samples acquired before and after training will be used to measure amino compounds and fatty acids. The results of this project will provide novel information about the metabolic changes associated with insulin resistance, obesity, and physical activity in young people who are at risk for, but have not yet developed cardiometabolic disease. The study design takes advantage of, and supports the scientific partnership among investigators at the University of Oklahoma Health Sciences Center, Choctaw Nation of Oklahoma, and Mayo Clinic Rochester. This will set the stage for future lifestyle intervention studies to further explore the concepts outlined in this proposal.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU000664 Subject (Entity type)	A subject from Metabolomics produced as part of the PR000458 project
	SU000663 Subject (Entity type)	A subject from Metabolomics produced as part of the PR000458 project
	SA036115 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000458 project
	SA036238 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000458 project
	SA036138 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000458 project
	SA036311 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000458 project
	SA036243 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000458 project
	SA036110 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000458 project
	SA036068 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000458 project