PR001583 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20250922.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M82X4B

Description:Phospholipase A2 group V (PLA2G5) is a secretory and Ca2+-dependent lipolytic enzyme and is inducible during several pathologic conditions. However, it has been unknown how PLA2G5 plays a role in sepsis. To study the role of PLA2G5 in sepsis, we performed lipidomics analysis of plasma and tissues from LPS-injected mice with or without PLA2G5 blockade. Here, we showed that PLA2G5 is involved in the production of fatty acids such as oleic acid and linoleic acid, lysophospholipids such as lysophosphatidic acid, lysophosphatidylcholine, lysophatidylethanolamine, and lysophosphatidylserine species, and metabolites derived from polyunsaturated fatty acids such as arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, and linoleic acids during sepsis. Thus, PLA2G5 regulates selective lipid pathways during sepsis.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU002544 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001583 project
	SA245710 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001583 project
	SA245659 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001583 project
	SA245654 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001583 project
	SA245700 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001583 project
	SA245712 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001583 project
	SA245660 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001583 project
	SA245672 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001583 project
	SA245664 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001583 project

PPR00001

Project (Entity type)

Metabolomics

SU002544

Subject (Entity type)

A subject from Metabolomics produced as part of the PR001583 project

SA245710

Biosample (Entity type)