LCK (Gene)

Description: LCK proto-oncogene, Src family tyrosine kinase

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View LCK's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with LCK.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using LCK.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for LCK.

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Gene Sets (1186)

LINCS L1000 Chem Pert Consensus Sigs (587)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (4)

A gene set library provided by IDG

LINCS L1000 CRISPR KO Consensus Sigs (540)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (5)

A gene set library provided by GTEx

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (8)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (1)

A gene set library provided by GTEx

IDG Drug Targets 2022 (41)

A gene set library provided by IDG

Knowledge Graph Assertions

Source	Relation	Target	Evidence
SID11110983 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)	0.0034709536
KFGENEBIN:LCK-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)
dihydrosamidin Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)	-0.009424519
catharanthine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)	0.027271079
1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)	-0.008279521
BAY 367620 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)	0.008185611
Entospletinib; 6-(1H-indazol-6-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)	0.0041705025
Honokiol Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)	-0.0041285986
1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)	0.003081108
SID11113468 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)	-0.007911506