CD3E (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)

Synonyms:CD3E, CD3e molecule, ENTREZ:916, HGNC:1674, IMD18, MIM:186830, NM_000733, NP_000724, T3E, TCRE

Omim:OMIM:186830

Nci:C24277

Id:ENSG00000198851

Hgnc:HGNC:1674

Entrez:916

Ensembl:ENSG00000198851

Description:CD3 epsilon subunit of T-cell receptor complex

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CD3E's neighborhood in the knowledge graph.

Submit

Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CD3E.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CD3E.

Submit

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CD3E.

Submit

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CD3E.

Results found

Linked to

	Label	Description
	T60-Adrenal Consensus Gene Set (Entity type)	A Gene Set from MoTrPAC
	GSE171837 bortezomib 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE182680 GSE182683 dexamethasone 10 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE171837 0 V 1 BORTEZOMIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE182680,GSE182683 10 V 3 DEXAMETHASONE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE182680 GSE182683 dexamethasone 5 v 11 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE191005 ENL knockout MOLM-13 1 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE114492 GSE153671 KMT2D inhibition 2 v 11 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE95077 amiloride 5 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	Sensorineural hearing impairment Phenotype (Entity type)	A type of hearing impairment in one or both ears related to an abnormal functionality of the cochlea...

T60-Adrenal Consensus

Gene Set (Entity type)

A Gene Set from MoTrPAC

GSE171837 bortezomib 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE182680 GSE182683 dexamethasone 10 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE171837 0 V 1 BORTEZOMIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE182680,GSE182683 10 V 3 DEXAMETHASONE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE182680 GSE182683 dexamethasone 5 v 11 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE191005 ENL knockout MOLM-13 1 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE114492 GSE153671 KMT2D inhibition 2 v 11 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE95077 amiloride 5 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Sensorineural hearing impairment

Phenotype (Entity type)

A type of hearing impairment in one or both ears related to an abnormal functionality of the cochlea...

DISPLAY PER PAGE

CFDE Workbench

Consortium

Community

Resources

@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.