TOX (Gene)

Ensembl Gene ID: ENSG00000198846

Entrez Gene ID: 9760

Description: thymocyte selection associated high mobility group box

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View TOX's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with TOX.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using TOX.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for TOX.

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Gene Sets (2630)

LINCS L1000 Chem Pert Consensus Sigs (671)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (1)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (11)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (596)

A gene set library provided by LINCS

rummageo gene perturbations (177)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (930)

A gene set library provided by LINCS

rummageo chemical perturbations (243)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (1)

A gene set library provided by MoTrPAC

Knowledge Graph Assertions

Source	Relation	Target	Evidence
SA-441350 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TOX Gene (Entity type)	0.015606126
(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TOX Gene (Entity type)	-0.02064119
kynurenic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TOX Gene (Entity type)	-0.0045327805
Swainsonine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TOX Gene (Entity type)	0.0039097117
kidney cortex collecting duct principal cell Anatomy (Entity type)	Has marker gene in kidney Knowledge Graph Relation (Entity type)	TOX Gene (Entity type)
2,6-Di-tert-butyl-4-[1-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-1-methyl-ethylsulfanyl]-phenol::2,6-di(tert-butyl)-4-{1-[3,5-di(tert-butyl)-4-hydroxyphenylsulfanyl]-1-methylethylsulfanyl}phenol::2,6-di(tert-butyl)-4-{1-[3,5-di(tert-butyl)-4-hydroxyphenylsulfanyl]-1-methylethylsulfanyl}phenol(probucol)::2,6-di-tert-butyl-4-(2-(3,5-di-tert-butyl-4-hydroxyphenylthio)propan-2-ylthio)phenol::CHEMBL608::DH-581::Lorelco::PROBUCOL::US9182402, 14 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TOX Gene (Entity type)	0.0042663254
haematoxylin-pentaacetate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TOX Gene (Entity type)	0.014831216
SA-1459291 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TOX Gene (Entity type)	0.0062626586
Olomoucine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TOX Gene (Entity type)	-0.0075744186
acefylline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TOX Gene (Entity type)	-0.023547344

SA-441350
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TOX
Gene (Entity type)
0.015606126

(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TOX
Gene (Entity type)
-0.02064119

kynurenic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TOX
Gene (Entity type)
-0.0045327805

Swainsonine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TOX
Gene (Entity type)
0.0039097117

kidney cortex collecting duct principal cell
Anatomy (Entity type)
Has marker gene in kidney
Knowledge Graph Relation (Entity type)
TOX
Gene (Entity type)

2,6-Di-tert-butyl-4-[1-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-1-methyl-ethylsulfanyl]-phenol::2,6-di(tert-butyl)-4-{1-[3,5-di(tert-butyl)-4-hydroxyphenylsulfanyl]-1-methylethylsulfanyl}phenol::2,6-di(tert-butyl)-4-{1-[3,5-di(tert-butyl)-4-hydroxyphenylsulfanyl]-1-methylethylsulfanyl}phenol(probucol)::2,6-di-tert-butyl-4-(2-(3,5-di-tert-butyl-4-hydroxyphenylthio)propan-2-ylthio)phenol::CHEMBL608::DH-581::Lorelco::PROBUCOL::US9182402, 14
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TOX
Gene (Entity type)
0.0042663254

haematoxylin-pentaacetate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TOX
Gene (Entity type)
0.014831216

SA-1459291
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TOX
Gene (Entity type)
0.0062626586

Olomoucine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TOX
Gene (Entity type)
-0.0075744186

acefylline
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TOX
Gene (Entity type)
-0.023547344

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Knowledge Graph Assertions

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

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