SERPINA1 (Gene)

Ensembl Gene ID: ENSG00000197249

Entrez Gene ID: 5265

Description: serpin family A member 1

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View SERPINA1's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with SERPINA1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using SERPINA1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for SERPINA1.

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Gene Sets (7570)

LINCS L1000 Chem Pert Consensus Sigs (2035)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (2)

A gene set library provided by IDG

GlyGen Glycosylated Proteins 2022 (88)

A gene set library provided by GlyGen

LINCS L1000 CRISPR KO Consensus Sigs (1903)

A gene set library provided by LINCS

rummageo gene perturbations (183)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (4)

A gene set library provided by GTEx

LINCS L1000 Consensus Median Signatures (3149)

A gene set library provided by LINCS

rummageo chemical perturbations (200)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (3)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (3)

A gene set library provided by GTEx

Knowledge Graph Assertions

Source	Relation	Target	Evidence
SA-85148 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SERPINA1 Gene (Entity type)	0.020627974
3-(2-cyano-3-(trifluoromethyl)phenoxy)phenyl 4,4,4-trifluorobutane-1-sulfonate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SERPINA1 Gene (Entity type)	-0.008284362
2-(4-(2-(1-cyclohexanebutyl)-3-cyclohexylureidoethyl)phenylthio)-2-methylpropionic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SERPINA1 Gene (Entity type)	0.008618805
tenidap Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SERPINA1 Gene (Entity type)	0.003358237
SID103904634 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SERPINA1 Gene (Entity type)	-0.012254252
lorazepam Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SERPINA1 Gene (Entity type)	-0.0033781596
3-(2,4-Dichloro-phenyl)-4-(1-methyl-1H-indol-3-yl)-pyrrole-2,5-dione Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SERPINA1 Gene (Entity type)	0.0072019817
SID87457340 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SERPINA1 Gene (Entity type)	-0.011586435
Tipifarnib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SERPINA1 Gene (Entity type)	-0.006446434
Inosine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SERPINA1 Gene (Entity type)	-0.0070478925

SA-85148
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SERPINA1
Gene (Entity type)
0.020627974

3-(2-cyano-3-(trifluoromethyl)phenoxy)phenyl 4,4,4-trifluorobutane-1-sulfonate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SERPINA1
Gene (Entity type)
-0.008284362

2-(4-(2-(1-cyclohexanebutyl)-3-cyclohexylureidoethyl)phenylthio)-2-methylpropionic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SERPINA1
Gene (Entity type)
0.008618805

tenidap
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SERPINA1
Gene (Entity type)
0.003358237

SID103904634
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SERPINA1
Gene (Entity type)
-0.012254252

lorazepam
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SERPINA1
Gene (Entity type)
-0.0033781596

3-(2,4-Dichloro-phenyl)-4-(1-methyl-1H-indol-3-yl)-pyrrole-2,5-dione
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SERPINA1
Gene (Entity type)
0.0072019817

SID87457340
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SERPINA1
Gene (Entity type)
-0.011586435

Tipifarnib
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SERPINA1
Gene (Entity type)
-0.006446434

Inosine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SERPINA1
Gene (Entity type)
-0.0070478925

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.