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HLA-DRB1 (Gene)

Ensembl Gene ID: ENSG00000196126

Entrez Gene ID: 3123

Description: major histocompatibility complex, class II, DR beta 1

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View HLA-DRB1's neighborhood in the knowledge graph.

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with HLA-DRB1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using HLA-DRB1.

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for HLA-DRB1.

Gene Sets (1529)

LINCS L1000 Chem Pert Consensus Sigs (355)

A gene set library provided by LINCS

Illuminating the Druggable Genome

ARCHS4 IDG Coexp (8)

A gene set library provided by IDG

LINCS L1000 CRISPR KO Consensus Sigs (247)

A gene set library provided by LINCS

rummageo gene perturbations (201)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (488)

A gene set library provided by LINCS

rummageo chemical perturbations (225)

A gene set library provided by LINCS

Human BioMolecular Atlas Program

HuBMAP ASCT-B (5)

A gene set library provided by HuBMAP

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	PCA 4248 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HLA-DRB1 Gene (Entity type)	0.0033392992
	N-{4-chloro-2-[(1-oxidopyridin-4-yl)carbonyl]phenyl}-4-(1,1-dimethylethyl)benzenesulfonamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HLA-DRB1 Gene (Entity type)	0.004684399
	Fenoldopam Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HLA-DRB1 Gene (Entity type)	0.0030101985
	SID11113966 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HLA-DRB1 Gene (Entity type)	-0.004822438
	Amlexanox Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HLA-DRB1 Gene (Entity type)	0.0049908487
	KFGENEBIN:HLA-DRB1-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	HLA-DRB1 Gene (Entity type)
	methyl (3aR,4S,7aR)-4-hydroxy-4-[(3-methylphenyl)ethynyl]octahydro-1H-indole-1-carboxylate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HLA-DRB1 Gene (Entity type)	0.005481951
	3-[(R)-3-(4-Fluoro-benzenesulfonylamino)-1,2,3,4-tetrahydro-carbazol-9-yl]-propionic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HLA-DRB1 Gene (Entity type)	0.0031351922
	cinoxacin Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HLA-DRB1 Gene (Entity type)	0.0041281036
	4-(4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HLA-DRB1 Gene (Entity type)	-0.006771224

PCA 4248
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HLA-DRB1
Gene (Entity type)
0.0033392992

N-{4-chloro-2-[(1-oxidopyridin-4-yl)carbonyl]phenyl}-4-(1,1-dimethylethyl)benzenesulfonamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HLA-DRB1
Gene (Entity type)
0.004684399

Fenoldopam
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HLA-DRB1
Gene (Entity type)
0.0030101985

SID11113966
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HLA-DRB1
Gene (Entity type)
-0.004822438

Amlexanox
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HLA-DRB1
Gene (Entity type)
0.0049908487

KFGENEBIN:HLA-DRB1-variant-count CUI
KFGENEBIN (Entity type)
Gene has variants
Knowledge Graph Relation (Entity type)
HLA-DRB1
Gene (Entity type)

methyl (3aR,4S,7aR)-4-hydroxy-4-[(3-methylphenyl)ethynyl]octahydro-1H-indole-1-carboxylate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HLA-DRB1
Gene (Entity type)
0.005481951

3-[(R)-3-(4-Fluoro-benzenesulfonylamino)-1,2,3,4-tetrahydro-carbazol-9-yl]-propionic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HLA-DRB1
Gene (Entity type)
0.0031351922

cinoxacin
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HLA-DRB1
Gene (Entity type)
0.0041281036

4-(4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HLA-DRB1
Gene (Entity type)
-0.006771224

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Resources

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.