Synonyms:CVID13, ENTREZ:10320, HGNC:13176, Hs.54452, IK1, IKAROS family zinc finger 1, IKAROS, IKZF1, LYF1, LyF-1, MIM:603023, NM_001220765, NM_001220766, NM_001220767, NM_001220768, NM_001220769, NM_001220770, NM_001220771, NM_001220772, NM_001220773, NM_001220774, NM_001220775, NM_001220776, NM_001291837, NM_001291838, NM_001291839, NM_001291840, NM_001291841, NM_001291842, NM_001291843, NM_001291844, NM_001291845, NM_001291846, NM_001291847, NM_006060, NP_001207694, NP_001207696, NP_001207697, NP_001207699, NP_001207700, NP_001278766, NP_001278767, NP_001278768, NP_001278769, NP_001278770, NP_001278771, NP_001278772, NP_001278773, NP_001278774, NP_001278775, NP_001278776, NP_006051, PPP1R92, PRO0758, XM_011515058, XM_011515059, XM_011515060, XM_011515061, XM_011515062, XM_011515063, XM_011515064, XM_011515065, XM_011515066, XM_011515067, XM_011515068, XM_011515069, XM_011515070, XM_011515071, XM_011515072, XM_011515073, XM_011515074, XM_011515075, XM_011515076, XM_011515077, XM_011515078, XM_017011667, XM_017011668, XM_017011669, XM_017011670, XP_011513360, XP_011513361, XP_011513362, XP_011513363, XP_011513364, XP_011513365, XP_011513366, XP_011513367, XP_011513368, XP_011513369, XP_011513370, XP_011513371, XP_011513372, XP_011513373, XP_011513374, XP_011513375, XP_011513376, XP_011513377, XP_011513378, XP_011513379, XP_011513380, XP_016867156, XP_016867157, XP_016867158, XP_016867159, ZNFN1A1
Omim:OMIM:603023
Id:ENSG00000185811
Hgnc:HGNC:13176
Description:IKAROS family zinc finger 1
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]
