RFX6 (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:222546, HGNC:21478, MIM:612659, MTCHRS, MTFS, NM_173560, NP_775831, RFX6, RFXDC1, XM_011535589, XM_017010477, XP_011533891, XP_016865966, dJ955L16.1, regulatory factor X6

Omim:OMIM:612659

Id:ENSG00000185002

Hgnc:HGNC:21478

Entrez:222546

Ensembl:ENSG00000185002

Description:regulatory factor X6

The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.[provided by RefSeq, Sep 2010]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View RFX6's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with RFX6.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using RFX6.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for RFX6.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with RFX6.

Results found

Linked to

	Label	Description
	GSE161800 cisplatin A-549 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE158834 ADIPOR2 knockout HEK293 0 v 9 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE150895 GSE150896 enzalutamide 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE151412 sorafenib 2 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE161800 0 V 1 CISPLATIN HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE208350 H-7 Huh-7 JHH-7 0 v 8 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE158834 0 V 9 PALMITIC ACID HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	Preweaning Lethality, Complete Penetrance (MP:0011100) Gene Set (Entity type)	A Gene Set from KOMP2
	GSE228430 FABP5 inhibition Huh-7 2 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE220097 enzalutamide LNCaP 4 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS

GSE161800 cisplatin A-549 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE158834 ADIPOR2 knockout HEK293 0 v 9 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE150895 GSE150896 enzalutamide 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE151412 sorafenib 2 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE161800 0 V 1 CISPLATIN HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE208350 H-7 Huh-7 JHH-7 0 v 8 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE158834 0 V 9 PALMITIC ACID HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Preweaning Lethality, Complete Penetrance (MP:0011100)

Gene Set (Entity type)

A Gene Set from KOMP2

GSE228430 FABP5 inhibition Huh-7 2 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE220097 enzalutamide LNCaP 4 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.