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LCK (Gene)

Ensembl Gene ID: ENSG00000182866

Entrez Gene ID: 3932

Description: LCK proto-oncogene, Src family tyrosine kinase

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View LCK's neighborhood in the knowledge graph.

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with LCK.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using LCK.

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for LCK.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Resources

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	SID11110983 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)	0.0034709536
	dihydrosamidin Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)	-0.009424519
	catharanthine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)	0.027271079
	KFGENEBIN:LCK-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)
	1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)	-0.008279521
	BAY 367620 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)	0.008185611
	Entospletinib; 6-(1H-indazol-6-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)	0.0041705025
	Honokiol Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)	-0.0041285986
	1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)	0.003081108
	SID11113468 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LCK Gene (Entity type)	-0.007911506

SID11110983
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LCK
Gene (Entity type)
0.0034709536

dihydrosamidin
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LCK
Gene (Entity type)
-0.009424519

catharanthine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LCK
Gene (Entity type)
0.027271079

KFGENEBIN:LCK-variant-count CUI
KFGENEBIN (Entity type)
Gene has variants
Knowledge Graph Relation (Entity type)
LCK
Gene (Entity type)

1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LCK
Gene (Entity type)
-0.008279521

BAY 367620
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LCK
Gene (Entity type)
0.008185611

Entospletinib; 6-(1H-indazol-6-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LCK
Gene (Entity type)
0.0041705025

Honokiol
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LCK
Gene (Entity type)
-0.0041285986

1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LCK
Gene (Entity type)
0.003081108

SID11113468
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LCK
Gene (Entity type)
-0.007911506

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