PRNP (Gene)

Entrez Gene ID: 5621

Description: prion protein (Kanno blood group)

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PRNP's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with PRNP.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PRNP.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PRNP.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PRNP.

Gene Sets (3124)

LINCS L1000 Chem Pert Consensus Sigs (399)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (11)

A gene set library provided by IDG

GlyGen Glycosylated Proteins 2022 (4)

A gene set library provided by GlyGen

LINCS L1000 CRISPR KO Consensus Sigs (544)

A gene set library provided by LINCS

rummageo gene perturbations (283)

A gene set library provided by LINCS

RummaGEO DrugPerturbations 2025 (843)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (550)

A gene set library provided by LINCS

rummageo chemical perturbations (479)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (5)

A gene set library provided by MoTrPAC

IDG Drug Targets 2022 (6)

A gene set library provided by IDG

Knowledge Graph Assertions

Source	Relation	Target	Evidence
eseroline Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PRNP Gene (Entity type)	0.020809822
Nifedipine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PRNP Gene (Entity type)	0.0038101275
Rebastinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PRNP Gene (Entity type)	0.004922702
Erythrosine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PRNP Gene (Entity type)	-0.010945575
YL-59 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PRNP Gene (Entity type)	-0.009829063
KFGENEBIN:PRNP-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	PRNP Gene (Entity type)
3-(4-Amino-3-methylbenzyl)-7-(2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PRNP Gene (Entity type)	-0.0061750826
sufentanil Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PRNP Gene (Entity type)	-0.005694937
hydrocortisone-phosphate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PRNP Gene (Entity type)	-0.010699491

eseroline
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PRNP
Gene (Entity type)
0.020809822

Nifedipine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PRNP
Gene (Entity type)
0.0038101275

Rebastinib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PRNP
Gene (Entity type)
0.004922702

Erythrosine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PRNP
Gene (Entity type)
-0.010945575

YL-59
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PRNP
Gene (Entity type)
-0.009829063

KFGENEBIN:PRNP-variant-count CUI
KFGENEBIN (Entity type)
Gene has variants
Knowledge Graph Relation (Entity type)
PRNP
Gene (Entity type)

3-(4-Amino-3-methylbenzyl)-7-(2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PRNP
Gene (Entity type)
-0.0061750826

sufentanil
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PRNP
Gene (Entity type)
-0.005694937

hydrocortisone-phosphate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PRNP
Gene (Entity type)
-0.010699491

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Knowledge Graph Assertions

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.