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CXCL8 (Gene)

Ensembl Gene ID: ENSG00000169429

Entrez Gene ID: 3576

Description: C-X-C motif chemokine ligand 8

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CXCL8's neighborhood in the knowledge graph.

Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CXCL8.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CXCL8.

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CXCL8.

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CXCL8.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

This repository is under review for potential modification in compliance with Administration directives.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	bupivacaine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CXCL8 Gene (Entity type)	-0.005877197
	cinobufagin Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CXCL8 Gene (Entity type)	0.024412593
	bufalin Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CXCL8 Gene (Entity type)	0.024853457
	CHIR-99021 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CXCL8 Gene (Entity type)	0.0072095613
	SA-1921574 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CXCL8 Gene (Entity type)	-0.016100606
	Tolazamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CXCL8 Gene (Entity type)	-0.003995507
	(2,3-dichlorophenyl)(5-methoxy-2-methyl-3-(2-morpholinoethyl)-1H-indol-1-yl)methanone Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CXCL8 Gene (Entity type)	0.007863443
	UTMB-00042 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CXCL8 Gene (Entity type)	-0.010370567
	5-Chloro-3-(4-methanesulfonyl-phenyl)-6''-methyl-[2,3'']bipyridinyl Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CXCL8 Gene (Entity type)	-0.0032489253
	KU-C103871 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CXCL8 Gene (Entity type)	0.012424654

bupivacaine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CXCL8
Gene (Entity type)
-0.005877197

cinobufagin
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CXCL8
Gene (Entity type)
0.024412593

bufalin
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CXCL8
Gene (Entity type)
0.024853457

CHIR-99021
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CXCL8
Gene (Entity type)
0.0072095613

SA-1921574
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CXCL8
Gene (Entity type)
-0.016100606

Tolazamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CXCL8
Gene (Entity type)
-0.003995507

(2,3-dichlorophenyl)(5-methoxy-2-methyl-3-(2-morpholinoethyl)-1H-indol-1-yl)methanone
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CXCL8
Gene (Entity type)
0.007863443

UTMB-00042
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CXCL8
Gene (Entity type)
-0.010370567

5-Chloro-3-(4-methanesulfonyl-phenyl)-6''-methyl-[2,3'']bipyridinyl
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CXCL8
Gene (Entity type)
-0.0032489253

KU-C103871
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CXCL8
Gene (Entity type)
0.012424654

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