PPIC (Gene)

Entrez Gene ID: 5480

Description: peptidylprolyl isomerase C

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PPIC's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with PPIC.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PPIC.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PPIC.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PPIC.

Gene Sets (1706)

LINCS L1000 Chem Pert Consensus Sigs (283)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (3)

A gene set library provided by IDG

GlyGen Glycosylated Proteins 2022 (4)

A gene set library provided by GlyGen

LINCS L1000 CRISPR KO Consensus Sigs (250)

A gene set library provided by LINCS

rummageo gene perturbations (166)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (1)

A gene set library provided by GTEx

RummaGEO DrugPerturbations 2025 (436)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (281)

A gene set library provided by LINCS

rummageo chemical perturbations (280)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (2)

A gene set library provided by MoTrPAC

Knowledge Graph Assertions

Source	Relation	Target	Evidence
KFGENEBIN:PPIC-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	PPIC Gene (Entity type)
GSK-1838705A Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PPIC Gene (Entity type)	-0.0043328023
costunolide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PPIC Gene (Entity type)	0.007875615
K-9944 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PPIC Gene (Entity type)	-0.018958194
(1S,3'R,4'S,5'S,6'R)-6-[(4-Ethylphenyl)methyl]-6'-(hydroxymethyl)-3',4',5',6'-tetrahydro-3H-spiro[2-benzofuran-1,2'-pyran]-3',4',5'-triol Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PPIC Gene (Entity type)	0.0070568426
givinostat Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PPIC Gene (Entity type)	0.010912353
Pimasertib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PPIC Gene (Entity type)	0.008793061
Dipeptidyl boronic acid derivative Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PPIC Gene (Entity type)	-0.0053575924
[[(1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl]-phenyl-phosphoryl]benzene Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PPIC Gene (Entity type)	-0.004562144

KFGENEBIN:PPIC-variant-count CUI
KFGENEBIN (Entity type)
Gene has variants
Knowledge Graph Relation (Entity type)
PPIC
Gene (Entity type)

GSK-1838705A
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PPIC
Gene (Entity type)
-0.0043328023

costunolide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PPIC
Gene (Entity type)
0.007875615

K-9944
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PPIC
Gene (Entity type)
-0.018958194

(1S,3'R,4'S,5'S,6'R)-6-[(4-Ethylphenyl)methyl]-6'-(hydroxymethyl)-3',4',5',6'-tetrahydro-3H-spiro[2-benzofuran-1,2'-pyran]-3',4',5'-triol
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PPIC
Gene (Entity type)
0.0070568426

givinostat
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PPIC
Gene (Entity type)
0.010912353

Pimasertib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PPIC
Gene (Entity type)
0.008793061

Dipeptidyl boronic acid derivative
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PPIC
Gene (Entity type)
-0.0053575924

[[(1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl]-phenyl-phosphoryl]benzene
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PPIC
Gene (Entity type)
-0.004562144

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Knowledge Graph Assertions

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.