CYP7A1 (Gene)

Organism:

Homo sapiens

Synonyms:CP7A, CYP7, CYP7A1, CYPVII, ENTREZ:1581, HGNC:2651, MIM:118455, NM_000780, NP_000771, cytochrome P450 family 7 subfamily A member 1

Omim:OMIM:118455

Id:ENSG00000167910

Hgnc:HGNC:2651

Entrez:1581

Ensembl:ENSG00000167910

Description:cytochrome P450 family 7 subfamily A member 1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CYP7A1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CYP7A1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CYP7A1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CYP7A1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CYP7A1.

Results found

Linked to

	Label	Description
	GSE125014 enzalutamide prostate gland 1 v 3 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE245677 CDK2 inhibition 2 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE158458 sorafenib 2 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE125014 1 V 3 ENZALUTAMIDE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE157594 5 V 7 NICOTINAMIDE MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE77108 saha 8 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE157594 6 V 2 NICOTINAMIDE MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE77108 8 V 2 SAHA HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE158458 2 V 1 SORAFENIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE199899 4 V 0 DIETHYLNITROSAMINE MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS

GSE125014 enzalutamide prostate gland 1 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE245677 CDK2 inhibition 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE158458 sorafenib 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE125014 1 V 3 ENZALUTAMIDE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE157594 5 V 7 NICOTINAMIDE MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE77108 saha 8 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE157594 6 V 2 NICOTINAMIDE MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE77108 8 V 2 SAHA HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE158458 2 V 1 SORAFENIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE199899 4 V 0 DIETHYLNITROSAMINE MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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