TIAM1 (Gene)

Entrez Gene ID: 7074

Description: TIAM Rac1 associated GEF 1

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View TIAM1's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with TIAM1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using TIAM1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for TIAM1.

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Gene Sets (1932)

LINCS L1000 Chem Pert Consensus Sigs (640)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (6)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (3)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (73)

A gene set library provided by LINCS

rummageo gene perturbations (179)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (707)

A gene set library provided by LINCS

rummageo chemical perturbations (314)

A gene set library provided by LINCS

GTEx Tissues V8 2023 (10)

A gene set library provided by GTEx

Knowledge Graph Assertions

Source	Relation	Target	Evidence
5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TIAM1 Gene (Entity type)	-0.015546594
imiloxan Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TIAM1 Gene (Entity type)	-0.0051843342
beta-CAROTENE Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TIAM1 Gene (Entity type)	-0.012509112
N-{4-[4-(Ethyl-heptyl-amino)-1-hydroxy-butyl]-phenyl}-methanesulfonamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TIAM1 Gene (Entity type)	0.0033579888
diphenhydramine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TIAM1 Gene (Entity type)	-0.011293762
VU-0403126 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TIAM1 Gene (Entity type)	-0.0102181025
ODQ Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TIAM1 Gene (Entity type)	0.009368565
retigabine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TIAM1 Gene (Entity type)	0.0028795735
emapunil Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TIAM1 Gene (Entity type)	-0.0030677512
SA-246522 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TIAM1 Gene (Entity type)	0.0120709315

5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TIAM1
Gene (Entity type)
-0.015546594

imiloxan
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TIAM1
Gene (Entity type)
-0.0051843342

beta-CAROTENE
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TIAM1
Gene (Entity type)
-0.012509112

N-{4-[4-(Ethyl-heptyl-amino)-1-hydroxy-butyl]-phenyl}-methanesulfonamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TIAM1
Gene (Entity type)
0.0033579888

diphenhydramine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TIAM1
Gene (Entity type)
-0.011293762

VU-0403126
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TIAM1
Gene (Entity type)
-0.0102181025

ODQ
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TIAM1
Gene (Entity type)
0.009368565

retigabine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TIAM1
Gene (Entity type)
0.0028795735

emapunil
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TIAM1
Gene (Entity type)
-0.0030677512

SA-246522
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TIAM1
Gene (Entity type)
0.0120709315

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Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.