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CFDE Workbench

MMP3 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:CHDS6, ENTREZ:4314, HGNC:7173, MIM:185250, MMP-3, MMP3, NM_002422, NP_002413, SL-1, STMY, STMY1, STR1, matrix metallopeptidase 3
Omim:OMIM:185250
Id:ENSG00000149968
Hgnc:HGNC:7173
Entrez:4314
Ensembl:ENSG00000149968
Description:matrix metallopeptidase 3
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View MMP3's neighborhood in the knowledge graph.

Submit
Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with MMP3.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using MMP3.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for MMP3.

Submit
Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with MMP3.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE218097 SOX10 overexpression glial cell 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE184892 trehalose fibroblast 4 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE206931 WDR5 inhibition WIN 8 v 7 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE149621 olaparib 3 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE128844 chloroquine 0 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE184892 4 V 2 TREHALOSE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE152699 GSE152723 vemurafenib 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE168171 GSE168173 DDX41 knockdown U2OS 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Phenotype

Sensorineural hearing impairment

Phenotype (Entity type)

A type of hearing impairment in one or both ears related to an abnormal functionality of the cochlea...

Gene Set

GSE183041 cisplatin 1 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE218097 SOX10 overexpression glial cell 2 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE184892 trehalose fibroblast 4 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE206931 WDR5 inhibition WIN 8 v 7 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE149621 olaparib 3 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE128844 chloroquine 0 v 3 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE184892 4 V 2 TREHALOSE HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE152699 GSE152723 vemurafenib 0 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE168171 GSE168173 DDX41 knockdown U2OS 0 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Phenotype

    Sensorineural hearing impairment

    Phenotype (Entity type)

    A type of hearing impairment in one or both ears related to an abnormal functionality of the cochlea...

  • Gene Set

    GSE183041 cisplatin 1 v 0 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

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    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.