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POLR2K (Gene)

Ensembl Gene ID: ENSG00000147669

Entrez Gene ID: 5440

Description: RNA polymerase II, I and III subunit K

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View POLR2K's neighborhood in the knowledge graph.

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with POLR2K.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using POLR2K.

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for POLR2K.

Gene Sets (637)

LINCS L1000 Chem Pert Consensus Sigs (223)

A gene set library provided by LINCS

Illuminating the Druggable Genome

ARCHS4 IDG Coexp (1)

A gene set library provided by IDG

LINCS L1000 CRISPR KO Consensus Sigs (48)

A gene set library provided by LINCS

rummageo gene perturbations (73)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (174)

A gene set library provided by LINCS

rummageo chemical perturbations (117)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (1)

A gene set library provided by MoTrPAC

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	BG-STK33-03 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	POLR2K Gene (Entity type)	0.027675908
	anthraquinone Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	POLR2K Gene (Entity type)	-0.03397255
	SA-1938111 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	POLR2K Gene (Entity type)	0.012230117
	palmatine-chloride Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	POLR2K Gene (Entity type)	-0.04056901
	NSC-625987 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	POLR2K Gene (Entity type)	0.03917332
	SA-1472321 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	POLR2K Gene (Entity type)	0.009943135
	SID855609 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	POLR2K Gene (Entity type)	0.05140934
	Chloroxylenol Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	POLR2K Gene (Entity type)	-0.03516438
	((4aR,10bR)-4-propyl-3,4,4a,10b-tetrahydro-2H,5H-chromeno[4,3-b][1,4]-oxazin-9-ol) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	POLR2K Gene (Entity type)	0.03467958
	MW-STK33-2B Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	POLR2K Gene (Entity type)	0.015368357

BG-STK33-03
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
POLR2K
Gene (Entity type)
0.027675908

anthraquinone
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
POLR2K
Gene (Entity type)
-0.03397255

SA-1938111
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
POLR2K
Gene (Entity type)
0.012230117

palmatine-chloride
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
POLR2K
Gene (Entity type)
-0.04056901

NSC-625987
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
POLR2K
Gene (Entity type)
0.03917332

SA-1472321
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
POLR2K
Gene (Entity type)
0.009943135

SID855609
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
POLR2K
Gene (Entity type)
0.05140934

Chloroxylenol
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
POLR2K
Gene (Entity type)
-0.03516438

((4aR,10bR)-4-propyl-3,4,4a,10b-tetrahydro-2H,5H-chromeno[4,3-b][1,4]-oxazin-9-ol)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
POLR2K
Gene (Entity type)
0.03467958

MW-STK33-2B
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
POLR2K
Gene (Entity type)
0.015368357

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.