SNCA (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:6622, HGNC:11138, MIM:163890, NACP, NM_000345, NM_001146054, NM_001146055, NM_001375285, NM_001375286, NM_001375287, NM_001375288, NM_001375290, NM_007308, NP_000336, NP_001139526, NP_001139527, NP_001362214, NP_001362215, NP_001362216, NP_001362217, NP_001362219, NP_009292, NR_164674, NR_164675, NR_164676, PARK1, PARK4, PD1, SNCA, XM_011532203, XM_011532204, XM_011532205, XM_011532206, XM_011532207, XM_017008563, XP_011530505, XP_011530506, XP_011530507, XP_011530508, XP_011530509, XP_016864052, synuclein alpha

Omim:OMIM:163890

Nci:C90101

Id:ENSG00000145335

Hgnc:HGNC:11138

Entrez:6622

Ensembl:ENSG00000145335

Description:synuclein alpha

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View SNCA's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with SNCA.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using SNCA.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for SNCA.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with SNCA.

Results found

Linked to

	Label	Description
	GSE233647 docetaxel UFERSA-PC3 DU145 4 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE252944 AKT inhibition 7 v 9 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE214505 AKR1B1 knockdown A-549 3 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE110709 GSK-J4 5 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE213588 trametinib NF1 8 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE248770 STIM1 knockout Hep 3B2.1-7 Sorafenib 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE248770 sorafenib Hep 3B2.1-7 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE146612 amiodarone 2 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE190178 MEK CDK8 inhibition 1 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE233647 4 V 0 DOCETAXEL HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS

GSE233647 docetaxel UFERSA-PC3 DU145 4 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE252944 AKT inhibition 7 v 9 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE214505 AKR1B1 knockdown A-549 3 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE110709 GSK-J4 5 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE213588 trametinib NF1 8 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE248770 STIM1 knockout Hep 3B2.1-7 Sorafenib 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE248770 sorafenib Hep 3B2.1-7 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE146612 amiodarone 2 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE190178 MEK CDK8 inhibition 1 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE233647 4 V 0 DOCETAXEL HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.