APP (Gene)

Entrez Gene ID: 351

Description: amyloid beta precursor protein

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View APP's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with APP.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using APP.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for APP.

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Gene Sets (857)

LINCS L1000 Chem Pert Consensus Sigs (34)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (15)

A gene set library provided by IDG

GlyGen Glycosylated Proteins 2022 (6)

A gene set library provided by GlyGen

KOMP2 Mouse Phenotypes 2022 (7)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (1)

A gene set library provided by LINCS

rummageo gene perturbations (240)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (37)

A gene set library provided by LINCS

rummageo chemical perturbations (508)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (2)

A gene set library provided by MoTrPAC

IDG Drug Targets 2022 (7)

A gene set library provided by IDG

Knowledge Graph Assertions

Source	Relation	Target	Evidence
rel-Milnacipran Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	APP Gene (Entity type)	-0.0043498767
1-(4-Fluoro-phenyl)-4-[4-(4-fluoro-phenyl)-piperazin-1-yl]-butan-1-ol Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	APP Gene (Entity type)	-0.0037934226
KFGENEBIN:APP-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	APP Gene (Entity type)
norgestrel Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	APP Gene (Entity type)	-0.0046394076
Penfluridol Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	APP Gene (Entity type)	-0.004332239

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Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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CFDE Workbench

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.