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DUSP6 (Gene)

Ensembl Gene ID: ENSG00000139318

Entrez Gene ID: 1848

Description: dual specificity phosphatase 6

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View DUSP6's neighborhood in the knowledge graph.

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with DUSP6.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using DUSP6.

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for DUSP6.

Gene Sets (2561)

LINCS L1000 Chem Pert Consensus Sigs (809)

A gene set library provided by LINCS

Illuminating the Druggable Genome

ARCHS4 IDG Coexp (3)

A gene set library provided by IDG

LINCS L1000 CRISPR KO Consensus Sigs (244)

A gene set library provided by LINCS

rummageo gene perturbations (330)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (705)

A gene set library provided by LINCS

rummageo chemical perturbations (460)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (1)

A gene set library provided by MoTrPAC

Genotype Tissue Expression

GTEx Tissues V8 2023 (8)

A gene set library provided by GTEx

Illuminating the Druggable Genome

IDG Drug Targets 2022 (1)

A gene set library provided by IDG

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DUSP6 Gene (Entity type)	-0.023800777
	MK-2206 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DUSP6 Gene (Entity type)	0.007814262
	(2,4-dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DUSP6 Gene (Entity type)	-0.012418304
	Levofloxacin Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DUSP6 Gene (Entity type)	0.0040984107
	N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DUSP6 Gene (Entity type)	0.004927039
	adapalene Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DUSP6 Gene (Entity type)	0.0056345947
	Sulfamethoxazole Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DUSP6 Gene (Entity type)	0.01095074
	N4-(3-Bromo-phenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DUSP6 Gene (Entity type)	-0.028809056
	GSK-1059615 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DUSP6 Gene (Entity type)	0.007553163
	1-(5-tert-Butyl-isoxazol-3-yl)-3-{4-[7-(2-morpholin-4-yl-ethoxy)-benzo[d]imidazo[2,1-b]thiazol-2-yl]-phenyl}-urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DUSP6 Gene (Entity type)	0.002789758

3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DUSP6
Gene (Entity type)
-0.023800777

MK-2206
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DUSP6
Gene (Entity type)
0.007814262

(2,4-dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DUSP6
Gene (Entity type)
-0.012418304

Levofloxacin
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DUSP6
Gene (Entity type)
0.0040984107

N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DUSP6
Gene (Entity type)
0.004927039

adapalene
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DUSP6
Gene (Entity type)
0.0056345947

Sulfamethoxazole
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DUSP6
Gene (Entity type)
0.01095074

N*4*-(3-Bromo-phenyl)-N*6*-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DUSP6
Gene (Entity type)
-0.028809056

GSK-1059615
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DUSP6
Gene (Entity type)
0.007553163

1-(5-tert-Butyl-isoxazol-3-yl)-3-{4-[7-(2-morpholin-4-yl-ethoxy)-benzo[d]imidazo[2,1-b]thiazol-2-yl]-phenyl}-urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DUSP6
Gene (Entity type)
0.002789758

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Resources

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.