TLR4 (Gene)

Entrez Gene ID: 7099

Description: toll like receptor 4

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View TLR4's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with TLR4.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using TLR4.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for TLR4.

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Gene Sets (6147)

LINCS L1000 Chem Pert Consensus Sigs (1917)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (14)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (4)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (762)

A gene set library provided by LINCS

rummageo gene perturbations (192)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (2)

A gene set library provided by GTEx

LINCS L1000 Consensus Median Signatures (3024)

A gene set library provided by LINCS

rummageo chemical perturbations (231)

A gene set library provided by LINCS

IDG Drug Targets 2022 (1)

A gene set library provided by IDG

Knowledge Graph Assertions

Source	Relation	Target	Evidence
Pemoline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	-0.008444417
SA-101776 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	0.031686
rel-Milnacipran Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	-0.005372375
norcyclobenzaprine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	-0.010531745
UBP-302 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	0.008786698
Tetrachloroethylene Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	-0.009845448
Sulfametopyrazine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	-0.021530092
monoethylhexylphthalate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	0.011603028
Hispidin Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	-0.01461531
Mepenzolate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	0.015154593

Pemoline
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TLR4
Gene (Entity type)
-0.008444417

SA-101776
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TLR4
Gene (Entity type)
0.031686

rel-Milnacipran
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TLR4
Gene (Entity type)
-0.005372375

norcyclobenzaprine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TLR4
Gene (Entity type)
-0.010531745

UBP-302
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TLR4
Gene (Entity type)
0.008786698

Tetrachloroethylene
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TLR4
Gene (Entity type)
-0.009845448

Sulfametopyrazine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TLR4
Gene (Entity type)
-0.021530092

monoethylhexylphthalate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TLR4
Gene (Entity type)
0.011603028

Hispidin
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TLR4
Gene (Entity type)
-0.01461531

Mepenzolate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TLR4
Gene (Entity type)
0.015154593

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Knowledge Graph Assertions

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CFDE Workbench

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.