DMTF1 (Gene)

Organism:

Homo sapiens

Synonyms:DMP1, DMTF, DMTF1, ENTREZ:9988, HGNC:14603, MIM:608491, MRUL, NM_001142326, NM_001142327, NM_021145, NP_001135798, NP_001135799, NP_066968, NR_024549, NR_024550, XM_011516735, XM_011516737, XM_011516739, XM_017012865, XM_017012866, XM_017012867, XM_017012868, XM_017012869, XM_017012870, XM_017012871, XM_017012872, XM_017012873, XM_017012874, XM_017012875, XM_017012876, XM_017012877, XM_017012878, XM_024447011, XM_024447012, XM_024447013, XM_024447014, XM_024447015, XM_024447016, XM_024447017, XM_024447018, XM_024447019, XM_024447020, XM_024447021, XM_024447022, XM_024447023, XM_024447024, XM_024447025, XM_024447026, XP_011515037, XP_011515039, XP_011515041, XP_016868354, XP_016868355, XP_016868356, XP_016868357, XP_016868358, XP_016868359, XP_016868360, XP_016868361, XP_016868362, XP_016868363, XP_016868364, XP_016868365, XP_016868366, XP_016868367, XP_024302779, XP_024302780, XP_024302781, XP_024302782, XP_024302783, XP_024302784, XP_024302785, XP_024302786, XP_024302787, XP_024302788, XP_024302789, XP_024302790, XP_024302791, XP_024302792, XP_024302793, XP_024302794, XR_001744895, XR_002956500, cyclin D binding myb like transcription factor 1, hDMP1

Omim:OMIM:608491

Id:ENSG00000135164

Hgnc:HGNC:14603

Entrez:9988

Ensembl:ENSG00000135164

Description:cyclin D binding myb like transcription factor 1

This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View DMTF1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with DMTF1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using DMTF1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for DMTF1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with DMTF1.

Results found

Linked to

	Label	Description
	GSE118548 trametinib T84 1 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE158632 quinoline HT-29 Caco-2 2 v 4 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE248770 STIM1 knockout Hep 3B2.1-7 Sorafenib 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE248770 sorafenib Hep 3B2.1-7 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE118548 1 V 2 TRAMETINIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE111247 temozolomide LN-308 2 v 7 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE147876 GSE147877 enzalutamide MR42D 2 v 10 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE235066 carboplatin 4 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE126463 pomalidomide MM1.S 6 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE159209 artemisinin stem cell 3 v 4 human dn Gene Set (Entity type)	A Gene Set from LINCS

GSE118548 trametinib T84 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE158632 quinoline HT-29 Caco-2 2 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE248770 STIM1 knockout Hep 3B2.1-7 Sorafenib 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE248770 sorafenib Hep 3B2.1-7 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE118548 1 V 2 TRAMETINIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE111247 temozolomide LN-308 2 v 7 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE147876 GSE147877 enzalutamide MR42D 2 v 10 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE235066 carboplatin 4 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE126463 pomalidomide MM1.S 6 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE159209 artemisinin stem cell 3 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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