DDB2 (Gene)

Entrez Gene ID: 1643

Description: damage specific DNA binding protein 2

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View DDB2's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with DDB2.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using DDB2.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for DDB2.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with DDB2.

Gene Sets (470)

LINCS L1000 Chem Pert Consensus Sigs (343)

A gene set library provided by LINCS

LINCS L1000 CRISPR KO Consensus Sigs (127)

A gene set library provided by LINCS

Knowledge Graph Assertions

Source	Relation	Target	Evidence
amsacrine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DDB2 Gene (Entity type)	0.014252856
[1,4']Bipiperidinyl-1'-carboxylic acid (S)-4,11-diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl ester Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DDB2 Gene (Entity type)	0.012607049
topotecan Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DDB2 Gene (Entity type)	0.02362716
2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,Ndimethylbenzenesulfonamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DDB2 Gene (Entity type)	-0.009209266
Fluorouracil Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DDB2 Gene (Entity type)	0.0040971707
Camptothecin Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DDB2 Gene (Entity type)	0.015107357
doxorubicin Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DDB2 Gene (Entity type)	0.010571315
Etoposide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DDB2 Gene (Entity type)	0.008098082
Selinexor Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DDB2 Gene (Entity type)	0.013154801
Ingenol Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DDB2 Gene (Entity type)	-0.01017062

amsacrine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DDB2
Gene (Entity type)
0.014252856

[1,4']Bipiperidinyl-1'-carboxylic acid (S)-4,11-diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl ester
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DDB2
Gene (Entity type)
0.012607049

topotecan
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DDB2
Gene (Entity type)
0.02362716

2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,Ndimethylbenzenesulfonamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DDB2
Gene (Entity type)
-0.009209266

Fluorouracil
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DDB2
Gene (Entity type)
0.0040971707

Camptothecin
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DDB2
Gene (Entity type)
0.015107357

doxorubicin
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DDB2
Gene (Entity type)
0.010571315

Etoposide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DDB2
Gene (Entity type)
0.008098082

Selinexor
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DDB2
Gene (Entity type)
0.013154801

Ingenol
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DDB2
Gene (Entity type)
-0.01017062

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Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

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