NOTCH2 (Gene)

Entrez Gene ID: 4853

Description: notch receptor 2

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View NOTCH2's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with NOTCH2.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using NOTCH2.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for NOTCH2.

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Gene Sets (2773)

LINCS L1000 Chem Pert Consensus Sigs (688)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (5)

A gene set library provided by IDG

GlyGen Glycosylated Proteins 2022 (3)

A gene set library provided by GlyGen

LINCS L1000 CRISPR KO Consensus Sigs (787)

A gene set library provided by LINCS

rummageo gene perturbations (211)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (783)

A gene set library provided by LINCS

rummageo chemical perturbations (291)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (5)

A gene set library provided by MoTrPAC

Knowledge Graph Assertions

Source	Relation	Target	Evidence
Nomifensine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	NOTCH2 Gene (Entity type)	0.0095794145
hydrocotarnine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	NOTCH2 Gene (Entity type)	-0.0095693115
2-(4-(4,4-bis(4-fluorophenyl)butyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	NOTCH2 Gene (Entity type)	0.0040037306
2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	NOTCH2 Gene (Entity type)	-0.0034158563
Gimeracil Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	NOTCH2 Gene (Entity type)	-0.0058629992
zosuquidar Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	NOTCH2 Gene (Entity type)	-0.0029218777
choline-alfoscerate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	NOTCH2 Gene (Entity type)	0.0038254142
Felbinac Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	NOTCH2 Gene (Entity type)	0.004289664
Enzalutamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	NOTCH2 Gene (Entity type)	0.0035227155
SA-1459975 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	NOTCH2 Gene (Entity type)	0.012114962

Nomifensine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
NOTCH2
Gene (Entity type)
0.0095794145

hydrocotarnine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
NOTCH2
Gene (Entity type)
-0.0095693115

2-(4-(4,4-bis(4-fluorophenyl)butyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
NOTCH2
Gene (Entity type)
0.0040037306

2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
NOTCH2
Gene (Entity type)
-0.0034158563

Gimeracil
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
NOTCH2
Gene (Entity type)
-0.0058629992

zosuquidar
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
NOTCH2
Gene (Entity type)
-0.0029218777

choline-alfoscerate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
NOTCH2
Gene (Entity type)
0.0038254142

Felbinac
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
NOTCH2
Gene (Entity type)
0.004289664

Enzalutamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
NOTCH2
Gene (Entity type)
0.0035227155

SA-1459975
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
NOTCH2
Gene (Entity type)
0.012114962

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Knowledge Graph Assertions

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.