IDO1 (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:3620, HGNC:6059, IDO, IDO-1, IDO1, INDO, MIM:147435, NM_002164, NP_002155, indoleamine 2, 3-dioxygenase 1

Omim:OMIM:147435

Nci:C79778

Id:ENSG00000131203

Hgnc:HGNC:6059

Entrez:3620

Ensembl:ENSG00000131203

Description:indoleamine 2,3-dioxygenase 1

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View IDO1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with IDO1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using IDO1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for IDO1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with IDO1.

Results found

Linked to

	Label	Description
	GSE146612 amiodarone 2 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE202434 GSE202438 talazoparib 9 v 5 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE207122 metformin 1 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE238213 dopamine 2 v 4 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE232435 TAK1 inhibition 0 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE218097 SOX10 overexpression glial cell 2 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE229674 FRA1 knockdown NCI-H1975 1 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE207122 1 V 0 METFORMIN HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE80802 EGFR inhibition Tankyrases 0 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE199107 tryptophan 3 v 5 human dn Gene Set (Entity type)	A Gene Set from LINCS

GSE146612 amiodarone 2 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE202434 GSE202438 talazoparib 9 v 5 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE207122 metformin 1 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE238213 dopamine 2 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE232435 TAK1 inhibition 0 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE218097 SOX10 overexpression glial cell 2 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE229674 FRA1 knockdown NCI-H1975 1 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE207122 1 V 0 METFORMIN HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE80802 EGFR inhibition Tankyrases 0 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE199107 tryptophan 3 v 5 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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