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TRPM4 (Gene)

Ensembl Gene ID: ENSG00000130529

Entrez Gene ID: 54795

Description: transient receptor potential cation channel subfamily M member 4

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View TRPM4's neighborhood in the knowledge graph.

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with TRPM4.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using TRPM4.

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for TRPM4.

Gene Sets (1476)

LINCS L1000 Chem Pert Consensus Sigs (376)

A gene set library provided by LINCS

Illuminating the Druggable Genome

ARCHS4 IDG Coexp (5)

A gene set library provided by IDG

LINCS L1000 CRISPR KO Consensus Sigs (260)

A gene set library provided by LINCS

rummageo gene perturbations (133)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (457)

A gene set library provided by LINCS

rummageo chemical perturbations (233)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (4)

A gene set library provided by MoTrPAC

Genotype Tissue Expression

GTEx Tissues V8 2023 (4)

A gene set library provided by GTEx

Illuminating the Druggable Genome

IDG Drug Targets 2022 (4)

A gene set library provided by IDG

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TRPM4 Gene (Entity type)	-0.0043794583
	(10R,13S)-17-Eth-(Z)-ylidene-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,16-dione Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TRPM4 Gene (Entity type)	-0.008690338
	AM251 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TRPM4 Gene (Entity type)	0.006078674
	US8987239, A::US9034856, A Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TRPM4 Gene (Entity type)	0.0033338836
	Alectinib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TRPM4 Gene (Entity type)	-0.0043287533
	KFGENEBIN:TRPM4-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	TRPM4 Gene (Entity type)
	napelline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TRPM4 Gene (Entity type)	-0.009163377
	Efatutazone Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TRPM4 Gene (Entity type)	-0.0074436218
	{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-phenoxy}-acetic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TRPM4 Gene (Entity type)	-0.0054293554
	tolfenamic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TRPM4 Gene (Entity type)	-0.0037590375

(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TRPM4
Gene (Entity type)
-0.0043794583

(10R,13S)-17-Eth-(Z)-ylidene-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,16-dione
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TRPM4
Gene (Entity type)
-0.008690338

AM251
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TRPM4
Gene (Entity type)
0.006078674

US8987239, A::US9034856, A
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TRPM4
Gene (Entity type)
0.0033338836

Alectinib
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TRPM4
Gene (Entity type)
-0.0043287533

KFGENEBIN:TRPM4-variant-count CUI
KFGENEBIN (Entity type)
Gene has variants
Knowledge Graph Relation (Entity type)
TRPM4
Gene (Entity type)

napelline
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TRPM4
Gene (Entity type)
-0.009163377

Efatutazone
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TRPM4
Gene (Entity type)
-0.0074436218

{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-phenoxy}-acetic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TRPM4
Gene (Entity type)
-0.0054293554

tolfenamic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TRPM4
Gene (Entity type)
-0.0037590375

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Resources

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.