APOE (Gene)

Entrez Gene ID: 348

Description: apolipoprotein E

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View APOE's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with APOE.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using APOE.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for APOE.

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Gene Sets (960)

LINCS L1000 Chem Pert Consensus Sigs (210)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (2)

A gene set library provided by IDG

GlyGen Glycosylated Proteins 2022 (6)

A gene set library provided by GlyGen

KOMP2 Mouse Phenotypes 2022 (9)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (21)

A gene set library provided by LINCS

rummageo gene perturbations (123)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (6)

A gene set library provided by GTEx

LINCS L1000 Consensus Median Signatures (391)

A gene set library provided by LINCS

rummageo chemical perturbations (182)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (5)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (5)

A gene set library provided by GTEx

Knowledge Graph Assertions

Source	Relation	Target	Evidence
3-Dibutylamino-1-(1,3-dichloro-6-trifluoromethyl-phenanthren-9-yl)-propan-1-ol Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	APOE Gene (Entity type)	0.0077216686
2-Butyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1,3-diaza-spiro[4.4]non-1-en-4-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	APOE Gene (Entity type)	0.0033405654
((4aR,10bR)-4-propyl-3,4,4a,10b-tetrahydro-2H,5H-chromeno[4,3-b][1,4]-oxazin-9-ol) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	APOE Gene (Entity type)	0.03651213
Dichlorophen Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	APOE Gene (Entity type)	-0.04046103
STK-222600 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	APOE Gene (Entity type)	-0.004403145
Empagliflozin Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	APOE Gene (Entity type)	-0.0040111
isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	APOE Gene (Entity type)	0.0037213964
Chloroxylenol Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	APOE Gene (Entity type)	-0.03574331
Ciprofloxacin Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	APOE Gene (Entity type)	-0.0045604995
Mitiglinide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	APOE Gene (Entity type)	-0.0063890815

3-Dibutylamino-1-(1,3-dichloro-6-trifluoromethyl-phenanthren-9-yl)-propan-1-ol
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
APOE
Gene (Entity type)
0.0077216686

2-Butyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1,3-diaza-spiro[4.4]non-1-en-4-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
APOE
Gene (Entity type)
0.0033405654

((4aR,10bR)-4-propyl-3,4,4a,10b-tetrahydro-2H,5H-chromeno[4,3-b][1,4]-oxazin-9-ol)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
APOE
Gene (Entity type)
0.03651213

Dichlorophen
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
APOE
Gene (Entity type)
-0.04046103

STK-222600
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
APOE
Gene (Entity type)
-0.004403145

Empagliflozin
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
APOE
Gene (Entity type)
-0.0040111

isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
APOE
Gene (Entity type)
0.0037213964

Chloroxylenol
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
APOE
Gene (Entity type)
-0.03574331

Ciprofloxacin
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
APOE
Gene (Entity type)
-0.0045604995

Mitiglinide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
APOE
Gene (Entity type)
-0.0063890815

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.