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CFDE Workbench

PTGIS (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:CYP8, CYP8A1, ENTREZ:5740, HGNC:9603, MIM:601699, NM_000961, NP_000952, PGIS, PTGI, PTGIS, prostaglandin I2 synthase
Omim:OMIM:601699
Id:ENSG00000124212
Hgnc:HGNC:9603
Entrez:5740
Ensembl:ENSG00000124212
Description:prostaglandin I2 synthase
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PTGIS's neighborhood in the knowledge graph.

Submit
Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with PTGIS.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PTGIS.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PTGIS.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PTGIS.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE218097 SOX10 overexpression glial cell 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE228619 cadherin-11 CDH11 knockdown RNA Small Interfering 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE135514 dasatinib 8 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE77108 saha 4 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE133749 BMPR2 overexpression endothelial cell 0 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE226115 GSE226116 doxorubicin cardiac endothelial cell 2 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE202434 GSE202438 talazoparib 15 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE214306 CCM1 knockout 5 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE77108 saha 8 v 9 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE233679 nicotinamide 6 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE218097 SOX10 overexpression glial cell 2 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE228619 cadherin-11 CDH11 knockdown RNA Small Interfering 0 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE135514 dasatinib 8 v 0 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE77108 saha 4 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE133749 BMPR2 overexpression endothelial cell 0 v 4 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE226115 GSE226116 doxorubicin cardiac endothelial cell 2 v 0 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE202434 GSE202438 talazoparib 15 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE214306 CCM1 knockout 5 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE77108 saha 8 v 9 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE233679 nicotinamide 6 v 0 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

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    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.