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CFDE Workbench

LIAS (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:ENTREZ:11019, HGCLAS, HGNC:16429, HUSSY-01, LAS, LIAS, LIP1, LS, MIM:607031, NM_001278590, NM_001278591, NM_001278592, NM_001363700, NM_006859, NM_194451, NP_001265519, NP_001265520, NP_001265521, NP_001350629, NP_006850, NP_919433, PDHLD, lipoic acid synthetase
Omim:OMIM:607031
Id:ENSG00000121897
Hgnc:HGNC:16429
Entrez:11019
Ensembl:ENSG00000121897
Description:lipoic acid synthetase
The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. Localized in the mitochondrion, this iron-sulfur enzyme catalyzes the final step in the de novo pathway for the biosynthesis of lipoic acid, a potent antioxidant. The deficient expression of this enzyme has been linked to conditions such as diabetes, atherosclerosis and neonatal-onset epilepsy. Alternative splicing occurs at this locus, and several transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Aug 2020]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View LIAS's neighborhood in the knowledge graph.

Submit
Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with LIAS.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using LIAS.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for LIAS.

Submit
Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with LIAS.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE153871 cytarabine U2OS 4 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE235587 mitoxantrone KYSE-70 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE153871 4 V 3 CYTARABINE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE217452 docetaxel 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE147662 3 V 5 NICOTINAMIDE MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE233679 nicotinamide 6 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE128099 GSE128159 gemcitabine SUM159PT 3 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE202434 GSE202438 talazoparib 13 v 5 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE213845 EZH2 inhibition 2 v 5 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE208350 H-7 Huh-7 JHH-7 0 v 8 human up

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE153871 cytarabine U2OS 4 v 3 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE235587 mitoxantrone KYSE-70 2 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE153871 4 V 3 CYTARABINE HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE217452 docetaxel 2 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE147662 3 V 5 NICOTINAMIDE MOUSE UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE233679 nicotinamide 6 v 0 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE128099 GSE128159 gemcitabine SUM159PT 3 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE202434 GSE202438 talazoparib 13 v 5 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE213845 EZH2 inhibition 2 v 5 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE208350 H-7 Huh-7 JHH-7 0 v 8 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

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    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.