ATF2 (Gene)

Organism:

Homo sapiens

Synonyms:ATF2, CRE-BP1, CREB-2, CREB2, ENTREZ:1386, HB16, HGNC:784, MIM:123811, NM_001256090, NM_001256091, NM_001256092, NM_001256093, NM_001256094, NM_001880, NP_001243019, NP_001243020, NP_001243021, NP_001243022, NP_001243023, NP_001871, NR_045768, NR_045769, NR_045770, NR_045771, NR_045772, NR_045773, NR_045774, TREB7, activating transcription factor 2

Omim:OMIM:123811

Id:ENSG00000115966

Hgnc:HGNC:784

Entrez:1386

Ensembl:ENSG00000115966

Description:activating transcription factor 2

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View ATF2's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with ATF2.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using ATF2.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for ATF2.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with ATF2.

Results found

Linked to

	Label	Description
	T60-Adrenal Consensus Gene Set (Entity type)	A Gene Set from MoTrPAC
	GSE228619 cadherin-11 CDH11 knockdown RNA Small Interfering 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE156648 DOT1L overexpression IMR-90 2 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE245968 FOXA1 inhibition Receptors Steroid Acetyltransferases 3 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE239688 canagliflozin 2 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE147876 GSE147877 enzalutamide MR42D 2 v 10 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE176008 pyridoxine 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE261563 CX-5461 5 v 8 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE202434 GSE202438 talazoparib 9 v 5 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE226115 GSE226116 doxorubicin cardiac endothelial cell 2 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS

T60-Adrenal Consensus

Gene Set (Entity type)

A Gene Set from MoTrPAC

GSE228619 cadherin-11 CDH11 knockdown RNA Small Interfering 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE156648 DOT1L overexpression IMR-90 2 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE245968 FOXA1 inhibition Receptors Steroid Acetyltransferases 3 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE239688 canagliflozin 2 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE147876 GSE147877 enzalutamide MR42D 2 v 10 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE176008 pyridoxine 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE261563 CX-5461 5 v 8 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE202434 GSE202438 talazoparib 9 v 5 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE226115 GSE226116 doxorubicin cardiac endothelial cell 2 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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