Information PortalData Portal

Data Matrix

Tools & Workflows

Documentation

HES1 (Gene)

Ensembl Gene ID: ENSG00000114315

Entrez Gene ID: 3280

Description: hes family bHLH transcription factor 1

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View HES1's neighborhood in the knowledge graph.

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with HES1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using HES1.

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for HES1.

Gene Sets (1608)

LINCS L1000 Chem Pert Consensus Sigs (480)

A gene set library provided by LINCS

Illuminating the Druggable Genome

ARCHS4 IDG Coexp (1)

A gene set library provided by IDG

LINCS L1000 CRISPR KO Consensus Sigs (124)

A gene set library provided by LINCS

rummageo gene perturbations (196)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (446)

A gene set library provided by LINCS

rummageo chemical perturbations (360)

A gene set library provided by LINCS

Genotype Tissue Expression

GTEx Tissues V8 2023 (1)

A gene set library provided by GTEx

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HES1 Gene (Entity type)	0.0046971543
	Propionic acid 6,9-difluoro-17-fluoromethylsulfanylcarbonyl-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester (Fluticasone Propionate, FP) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HES1 Gene (Entity type)	-0.006100945
	2-methyl-6-(phenylethynyl)pyridine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HES1 Gene (Entity type)	-0.004910876
	Diacerein Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HES1 Gene (Entity type)	0.0040961285
	radicicol Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HES1 Gene (Entity type)	-0.009095489
	Narciclasine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HES1 Gene (Entity type)	0.029236412
	batimastat Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HES1 Gene (Entity type)	-0.0053220033
	UCN-01 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HES1 Gene (Entity type)	-0.009902288
	KFGENEBIN:HES1-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	HES1 Gene (Entity type)
	epothilone-a Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HES1 Gene (Entity type)	-0.013706457

1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HES1
Gene (Entity type)
0.0046971543

Propionic acid 6,9-difluoro-17-fluoromethylsulfanylcarbonyl-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester (Fluticasone Propionate, FP)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HES1
Gene (Entity type)
-0.006100945

2-methyl-6-(phenylethynyl)pyridine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HES1
Gene (Entity type)
-0.004910876

Diacerein
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HES1
Gene (Entity type)
0.0040961285

radicicol
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HES1
Gene (Entity type)
-0.009095489

Narciclasine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HES1
Gene (Entity type)
0.029236412

batimastat
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HES1
Gene (Entity type)
-0.0053220033

UCN-01
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HES1
Gene (Entity type)
-0.009902288

KFGENEBIN:HES1-variant-count CUI
KFGENEBIN (Entity type)
Gene has variants
Knowledge Graph Relation (Entity type)
HES1
Gene (Entity type)

epothilone-a
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HES1
Gene (Entity type)
-0.013706457

DISPLAY PER PAGE

Consortium

Community

Resources

@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.