LOX (Gene)

Entrez Gene ID: 4015

Description: lysyl oxidase

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View LOX's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with LOX.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using LOX.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for LOX.

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Gene Sets (3768)

LINCS L1000 Chem Pert Consensus Sigs (1029)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (6)

A gene set library provided by IDG

GlyGen Glycosylated Proteins 2022 (15)

A gene set library provided by GlyGen

KOMP2 Mouse Phenotypes 2022 (10)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (795)

A gene set library provided by LINCS

rummageo gene perturbations (195)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (1)

A gene set library provided by GTEx

LINCS L1000 Consensus Median Signatures (1395)

A gene set library provided by LINCS

rummageo chemical perturbations (304)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (3)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (12)

A gene set library provided by GTEx

IDG Drug Targets 2022 (3)

A gene set library provided by IDG

Knowledge Graph Assertions

Source	Relation	Target	Evidence
(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LOX Gene (Entity type)	-0.02189636
6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-alpha]-benzimidazole-2-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LOX Gene (Entity type)	-0.004150225
Miltefosine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LOX Gene (Entity type)	0.0048986184
Isoproterenol Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LOX Gene (Entity type)	-0.019664122
Ro-60-0175 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LOX Gene (Entity type)	-0.008890684
(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LOX Gene (Entity type)	-0.009223332
olvanil Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LOX Gene (Entity type)	0.011010524
SA-440968 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LOX Gene (Entity type)	-0.013074692
YL-60 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LOX Gene (Entity type)	-0.011908456
Bimatoprost Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LOX Gene (Entity type)	0.0030025824

(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LOX
Gene (Entity type)
-0.02189636

6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-alpha]-benzimidazole-2-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LOX
Gene (Entity type)
-0.004150225

Miltefosine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LOX
Gene (Entity type)
0.0048986184

Isoproterenol
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LOX
Gene (Entity type)
-0.019664122

Ro-60-0175
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LOX
Gene (Entity type)
-0.008890684

(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LOX
Gene (Entity type)
-0.009223332

olvanil
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LOX
Gene (Entity type)
0.011010524

SA-440968
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LOX
Gene (Entity type)
-0.013074692

YL-60
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LOX
Gene (Entity type)
-0.011908456

Bimatoprost
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LOX
Gene (Entity type)
0.0030025824

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.