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CCL2 (Gene)

Ensembl Gene ID: ENSG00000108691

Entrez Gene ID: 6347

Description: C-C motif chemokine ligand 2

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CCL2's neighborhood in the knowledge graph.

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CCL2.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CCL2.

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CCL2.

Gene Sets (2315)

LINCS L1000 Chem Pert Consensus Sigs (804)

A gene set library provided by LINCS

Illuminating the Druggable Genome

ARCHS4 IDG Coexp (3)

A gene set library provided by IDG

LINCS L1000 CRISPR KO Consensus Sigs (371)

A gene set library provided by LINCS

rummageo gene perturbations (163)

A gene set library provided by LINCS

Genotype Tissue Expression

GTEx Aging Signatures 2021 (16)

A gene set library provided by GTEx

LINCS L1000 Consensus Median Signatures (677)

A gene set library provided by LINCS

rummageo chemical perturbations (273)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (1)

A gene set library provided by MoTrPAC

Genotype Tissue Expression

GTEx Tissues V8 2023 (6)

A gene set library provided by GTEx

Illuminating the Druggable Genome

IDG Drug Targets 2022 (1)

A gene set library provided by IDG

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	Tolmetin Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CCL2 Gene (Entity type)	-0.005385725
	ciclesonide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CCL2 Gene (Entity type)	-0.010712824
	oncrasin-1 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CCL2 Gene (Entity type)	-0.0071670706
	5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CCL2 Gene (Entity type)	0.019801037
	SID11112245 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CCL2 Gene (Entity type)	0.02782529
	flunisolide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CCL2 Gene (Entity type)	-0.0055402615
	5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CCL2 Gene (Entity type)	-0.016102
	Propionic acid 6,9-difluoro-17-fluoromethylsulfanylcarbonyl-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester (Fluticasone Propionate, FP) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CCL2 Gene (Entity type)	-0.0076017426
	Beta-alanine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CCL2 Gene (Entity type)	-0.022960693
	Dalcetrapib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CCL2 Gene (Entity type)	0.0060062506

Tolmetin
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CCL2
Gene (Entity type)
-0.005385725

ciclesonide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CCL2
Gene (Entity type)
-0.010712824

oncrasin-1
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CCL2
Gene (Entity type)
-0.0071670706

5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CCL2
Gene (Entity type)
0.019801037

SID11112245
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CCL2
Gene (Entity type)
0.02782529

flunisolide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CCL2
Gene (Entity type)
-0.0055402615

5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CCL2
Gene (Entity type)
-0.016102

Propionic acid 6,9-difluoro-17-fluoromethylsulfanylcarbonyl-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester (Fluticasone Propionate, FP)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CCL2
Gene (Entity type)
-0.0076017426

Beta-alanine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CCL2
Gene (Entity type)
-0.022960693

Dalcetrapib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CCL2
Gene (Entity type)
0.0060062506

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.